Widely found in plant tissues, phenolic compounds tend to be aromatic and contribute to the color, flavor and acidity of fruits. Anthocyanins are one class of phenols, and studies have associated the consumption of anthocyanin-rich foods with reduced risks of cardiovascular disease, type 2 diabetes and certain types of cancer. Scientists at the University of Illinois, led by food science professor Elvira Gonzalez de Mejia and crop sciences professor John Juvik, have developed new hybrids of purple corn containing different combinations of phytochemicals that may fight obesity, inflammation and diabetes. The pericarp – or outer layer – of purple and other brightly colored corn kernels also may provide an alternative source of colorants for food products, giving corn producers another value-added product from their crop. From a strain of maize called Apache Red, Juvik’s team bred 20 genetic varieties of purple corn, each with a unique combination of anthocyanins, the nutritious natural pigments that give the pericarp its vibrant color.
Using pressurized water, postdoctoral researches extracted the anthocyanins from the pericarp of the corn kernels, creating anthocyanin-rich water extracts that were then freeze-dried. While analyses of the extracts showed that the pericarp is an abundant source of anthocyanins and phenolic compounds, the concentration varied significantly among the varieties. To examine the impact of anthocyanins on obesity-induced inflammation, then-graduate student and first author of the study Qiaozhi Zhang combined fat cell or adipocytes from mice with large immune cells called macrophages. The mouse cell models in the study simulated those of obese people with high concentrations of lipids and inflammation in their cells, or healthy individuals who regularly eat plants containing phenolic compounds. They observed that the phenolic compounds in the extracts altered the cells’ development, reducing the adipocytes’ fat content from 8 to 56%, depending on the differing phenols used.
To study the compounds’ impact on insulin resistance, the scientists used a cell-signaling protein to induce insulin resistance in the mouse fat cells, then treated the cells with the anthocyanins and monitored their glucose uptake. A key marker of insulin resistance decreased by 50% and cellular glucose uptake decreased by 80%, depending on the chemical composition of the anthocyanins used. Researcher observed very important changes in molecules that reduced oxidative stress and inflammation in the insulin-resistant adipocytes, and also in pro-inflammatory molecules of the immune cells. The findings suggested that different levels and chemical compositions of these phenolic compounds might prevent obesity or improve the insulin profile of people who are obese. Flavonoids like quercetin, luteolin and rutin (common in many plant foods) played key roles in reducing some of the obesity, inflammation and some biomarkers of type 2. Phenolics such as vanillic and protocatechuic acid, decreased the potential conversion of pre-adipocytes to adipocytes.
Dr. Juvik commented the implication of his research: “We are currently performing genomic selection to identify the DNA markers associated with the most promising health effects in order to breed corn hybrids with those properties. In addition to its health-promoting properties, the pericarp of red an, purple corn could serve as natural pigments for the food industry, satisfying strong consumer demand for alternatives to synthetic dyes. We calculated that all of the red dye No. 40 (among tha mains used in the U.S.) could be replaced with the pigment derived from about 600,000 acres of corn. And we could produce the anthocyanin-rich pericarp in sufficient quantities for manufacturers to add it to beverages or special products with pharmaceutical properties. The advantage to using water to extract the anthocyanins from the pericarp is that it’s the most simple, straightforward and inexpensive way for industry to remove these compounds, compared with other extraction protocols that are complicated and more expensive. Water extraction is also a “green” process, compliant with environmental and food and drug regulations”.
- Edited by Dr. Gianfrancesco Cormaci, PhD, specialist in Clinical Biochemistry.
Zhang Q et al. Food Chem. 2019 Aug 15; 289:739-750.
Fernandez-Aulis F et al. J Food Science 2019; Apr 17.
Chatham L et al. J Agric Food Chem. 2018; 66(41):10844.
Dott. Gianfrancesco Cormaci
Ultimi post di Dott. Gianfrancesco Cormaci (vedi tutti)
- Indagini sul diabete tipo 2: oltre al tipo 1, anche genetica e virus intervengono in questa forma? - Maggio 16, 2022
- Toxoplasmosi e le sue forme: il pericolo odierno che rappresenta e gli sforzi in campo per combatterla - Maggio 16, 2022
- Melasma management: tranexamic acid to overtake expectances through the treatments’ list - Maggio 15, 2022
- Cronicizzazione di asma, BPCO e altre condizioni polmonari: ecco svelato il colpevole rimasto nell’ombra - Maggio 13, 2022
- Antidolorifici per trattare il dolore: è davvero il modo giusto? Le vecchie tesi sfidate dalle nuove scoperte - Maggio 13, 2022