HomeENGLISH MAGAZINECognitive reserve: decline or not, brain enterprising rescue it from warping

Cognitive reserve: decline or not, brain enterprising rescue it from warping

Dementia is a syndrome and an umbrella term for many diseases that affect memory, cognitive abilities and behavior. These alternations in brain functions significantly interfere with a person’s ability to maintain their activities of daily living (ADLs). Today, dementia is the 5th leading cause of death across the globe and an estimated 50 million people are living with dementia, costing a total of $818 billion in terms of care provided by family and other caregivers. The number is expected to triple in 2050. Even though age is the strongest known risk for dementia, it’s not a normal part of aging. In fact, it’s the loss of cognitive functioning, which includes the ability to remember, solve problems, think, and reason. The functions affected by dementia include memory, problem-solving, visual perception, language skills, ability to focus or pay attention and self-management. The cognitive reserve (CR) hypothesis is a compensatory mechanism to cope with age-related brain damage. It has been proposed to explain why some individuals maintain better cognitive function even with brain changes brought by aging or any disease process. Now, a new study performed by a team of researchers at the Tianjin Medical University in China, found higher cumulative lifetime cognitive reserve decreased the risk of dementia.

Scientists wanted to explore whether accumulation over a lifetime of cognitive and social activities are linked to a slower rate of memory loss, hence, a lower risk of developing dementia, despite brain pathologies. The study, which was published in the JAMA Neurology, shows that older individuals who have the highest lifespan cognitive reserve had a 39% reduced risk of dementia, compared to those with the lowest scores. Despite having vascular pathology or Alzheimer’s disease (AD), there was less dementia risk if the senior had high scores in lifespan cognitive reserve. The researchers explained that in this community-based prospective study of dementia-free older adults, they found that high lifespan CR indicator accumulated through education, early-life cognitive activities, midlife cognitive activities, late-life cognitive activities, and social activities in late life was associated with a reduction in risk of dementia in a dose-dependent manner. To land to their findings and make a cumulative cognitive reserve measurement in the lifetime, the researchers enrolled a total of 2,022 participants in the Rush Memory and Aging Project, which is a current community-based cohort study. The participants had an annual follow up between 1997 and 2018.

After excluding patients who were not qualified in the study criteria, they were left with 1,602 patients without dementia, the majority are women and had a mean age of 80. Upon follow-up, a total of 747 had died and of these, 611 underwent autopsies. The researchers then examined the reports and data between May and September 2018. The lifespan cognitive reserve score incorporated education, social activities in late life, a social network in late life, and early-life, midlife, and late-life cognitive activities. The team measured the lifespan CR score and divided them into tertiles, ranked lowest, middle, and highest. Of the 1,602 participants, 389 participants developed dementia, including 357 who developed Alzheimer’s disease. Compared to those with high brain pathologies but with lowest CR score tertile, the dementia rate was about 38 to 55% lower in individuals both in the highest CT score tertile and high brain pathologies. The researchers found that the highest cognitive reserve score was linked to a reduced risk of dementia, even among those with high Alzheimer’s disease pathology. This means that cognitive reserve, which included education, cognitive activities, social networks, and social activities may reduce the risk of developing dementia.

They also stated that cognitive reserve was not linked to most brain pathologies and the link of CR with dementia remained significant even after adjustments with these brain pathologies. Lastly, they found that CR may be linked to a reduced risk of dementia even with high Alzheimer’s disease and vascular pathologies such as infarcts. The study authors concluded that accumulative educational and mentally stimulating activities enhancing CR throughout life might be a feasible strategy to prevent dementia, even in people with high AD or vascular pathologies. Further large population-based longitudinal studies are warranted to establish the strategies of engagement in CR-related activities for the prevention of dementia.

  • Edited by Dr. Gianfrancesco Cormaci, PhD, specialist in Clinical Biochemistry.

Scientific references

Xu H, Yang R et al. JAMA Neurol. 2019 Jul 14.

Dekhtyar S et al. Ann Neurol. 2019 Jul; 86(1):68-78.

van Loenhoud AC et al. Neurology. 2019 Jul 2.

Wang Y et al. Front Aging Neurosci. 2019;11:129.

Dott. Gianfrancesco Cormaci
- Laurea in Medicina e Chirurgia nel 1998 (MD Degree in 1998) - Specialista in Biochimica Clinica nel 2002 (Clinical Biochemistry residency in 2002) - Dottorato in Neurobiologia nel 2006 (Neurobiology PhD in 2006) - Ha soggiornato negli Stati Uniti, Baltimora (MD) come ricercatore alle dipendenze del National Institute on Drug Abuse (NIDA/NIH) e poi alla Johns Hopkins University, dal 2004 al 2008. - Dal 2009 si occupa di Medicina personalizzata. - Guardia medica presso strutture private dal 2010 - Detentore di due brevetti sulla preparazione di prodotti gluten-free a partire da regolare farina di frumento immunologicamente neutralizzata (owner of patents concerning the production of bakery gluten-free products, starting from regular wheat flour). - Responsabile del reparto Ricerca e Sviluppo per la società CoFood s.r.l. (leader of the R&D for the partnership CoFood s.r.l.) - Autore di un libro riguardante la salute e l'alimentazione, con approfondimenti su come questa condizioni tutti i sistemi corporei. - Autore di articoli su informazione medica e salute sui siti web salutesicilia.com, medicomunicare.it e in lingua inglese sul sito www.medicomunicare.com
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