Stressful life against brain structure: astrocytes show how misbehavior “takes shape”

Not all the cells in the brain are neurons. Averagely a 40% of them are glial cells. The name comes from the Greek word “glía,” which means “glue.” Scientists gave them this name because they initially believed that glial cells simply held the brain’s neurons together. Subsequent research suggests that their role was far more complex. Scientists have identified four major types of glial cells: astrocytes, microglia, oligodendrocytes and NG2-glia. Astrocytes are the most abundant type of glial cell and are critical for the formation and maintenance of synaptic connections. These star-shaped cells have limbs, or “fine processes,” that extend outward from the cell’s center. Their metabolism is litterally at neurons’ service. Research shows that when astrocytes are unavailable to neurons, these degrade and eventually die. A brain’s neurons form connections, or “synapses,” through which they chemically exchange information. The upstream, or “presynaptic” neuron releases chemicals (neurotransmitters) that bind with receptors on a downstream, or “postsynaptic” second neuron. However, astrocytes are the third partner in the process.

The astrocytes’ involvement in communication between two neurons is so important, scientists describe the connection as a “tripartite synapse”. Scientists are still investigating the full role of astrocytes in synaptic connections, though they are aware of some of their contributions. When astrocytes’ extend their fine processes outward to touch their synaptic neuron partners, they regulate synaptic transmission by interacting with neurons’ excitatory and inhibitory chemicals. They also clear away buildup of no-longer-needed neurotransmitters after they have delivered their message. Astrocytes also provide nutrients to neurons and help them retain plasticity, as well as helping maintain the blood-brain barrier. Dr. Si-Qiong June Liu of LSU Health New Orleans School of Medicine is the lead author of a new study on mice that reveals at least one way in which stress physiologically changes the way a brain operates. In research with mice, Liu’s study finds that even a single stressful event can quickly cause long-lasting changes to an astrocyte. The journal for neuroscience JNeurosci has published the research.

When experiencing stress, the astrocytes shrink away from synapses resulting in disruption of neural communication. Synapses are structures that allow information to pass from one cell to another via neurotransmitters. Researchers will need to carry out further studies to see whether the effect of stress on mice is the same as it is on humans. Liu notes, however, that there is a good chance that the molecular pathways involved in her research also exist in humans. Liu’s team saw that when they exposed the mice to the odor of a predator even one time, the stress produced a long-lasting change to their astrocytes. In response to the stress, the mice secreted the stress hormone norepinephrine, which, in turn, suppressed a molecular pathway that produces a protein called GluA1. GluA1 controls the shaping and plasticity of the astrocytes; in particular, it controls the extension of the astrocytic fibers. Now, astrocytes’ fine processes retracted in response to stress and pulled away from contact and communication with neurons and synapses. This made synaptic connections more difficult or impossible.

Curiously stress is based in our body on the answers triggered by two main chemicals: norepinephrine (nor-adrenaline) and the steroid hormone cortisol. This last is implicated in several aspects of both carbohydrate and lipid metabolism; it is considered as an antagonist of insulin and it raises blood sugar concentrations. However, in the brain its role is more wide: cortisol is a steroid hormone and it works through inner cellular receptors. Once bound to them, it activates a pattern of gene expression responses that in neurons may flow in events like metabolic changes, cytoskeletal rearragnements, synaptic plasticity and, if the stimualtion is prolonged, even in neuronal death. Commonly glucocorticoids affect neuronal metabolism, they may change the expression of enzymes involved in neurotransmitter networks (mono-aminoxidase, acetyl-transferases, aromatic hydroxylases, etc.), thus affecting important mediators like dopamine, norepinephrine and serotonin. All these control mood and other higher congnitive functions like memory, behavior and the like. Traumatic or sustained stressful events may enhance all the aforementioned processes and lead to psychological disturbances.

Dr Liu explained thoroughly: “The experience of traumatic events can lead to neuropsychiatric disorders, including anxiety, depression and drug addiction. Stress alters brain function and produces lasting changes in human behavior and physiology. Investigation of the neurobiology of stress can reveal how stress affects neuronal connections and hence brain function. This knowledge is necessary for developing strategies to prevent or treat these common stress-related neurological disorders. Stress affects the structure and function of both neurons and astrocytes: because astrocytes can directly modulate synaptic transmission and are critically involved in stress-related behavior, preventing or reversing the stress-induced change in astrocytes is a potential way to treat stress-related neurological disorders. Being aware of the interplay between stress, norepinephrine and GluA1 can provide a new therapeutic avenue to explore. This suggests new pharmacological targets for possible prevention or reversal of stress-induced changes”.

  • Edited by Dr. Dr. Gianfrancesco Cormaci, PhD, specialist in Clinical Biochemistry.

Scientific references

Bender CL, Sun X et al. J Neurosci. 2020 Apr; 40(17):3374-84.

Yang L, Wang J et al. Behav Brain Res. 2020 Apr 25:112644.

Chen Y, Qin C et al. Cell Proliferation 2020 Mar; 53(3):e12781.

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Informazioni su Dott. Gianfrancesco Cormaci 2445 Articoli
- Laurea in Medicina e Chirurgia nel 1998 (MD Degree in 1998) - Specialista in Biochimica Clinica nel 2002 (Clinical Biochemistry specialty in 2002) - Dottorato in Neurobiologia nel 2006 (Neurobiology PhD in 2006) - Ha soggiornato negli Stati Uniti, Baltimora (MD) come ricercatore alle dipendenze del National Institute on Drug Abuse (NIDA/NIH) e poi alla Johns Hopkins University, dal 2004 al 2008. - Dal 2009 si occupa di Medicina personalizzata. - Detentore di un brevetto sulla preparazione di prodotti gluten-free a partire da regolare farina di frumento immunologicamente neutralizzata (owner of a patent concerning the production of bakery gluten-free products, starting from regular wheat flour). - Responsabile del reparto Ricerca e Sviluppo per la società CoFood s.r.l. (leader of the R&D for the partnership CoFood s.r.l.) - Autore di un libro riguardante la salute e l'alimentazione, con approfondimenti su come questa condizioni tutti i sistemi corporei. - Autore di articoli su informazione medica, salute e benessere sui siti web salutesicilia.com e medicomunicare.it
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