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Marrow Stem Akt: researchers MAPKing signaling tRAFfic to find answers AT RApid pace

All-trans retinoic acid (ATRA), an active metabolite of vitamin A, regulates gene expression in a number of physiological processes, including embryogenesis, vision, growth, skin...

On the role of nicotine in cancer: is it all a smoke screen?

Nicotine, a major component in tobacco, has been implicated as a potential factor that promotes the development of lung cancer. Studies have shown that...

Circadians: keymasters and gatekeepers of the breast cancer

A group of genes that code for different proteins found in many of our tissues and organs, our biological clocks regulate our circadian rhythms....

Cellular energy: the evolutionary immune rheostat that likes to play under the moonlight

The first step in glycolysis is the phosphorylation of glucose, catalyzed by hexokinase (HK). There are four isoforms of HKs. While every kind of...

Against aggressive cancers: a game of thrones where the humble glutamine becomes the queen

Up to 60% of ovarian clear cell carcinomas (OCCC) have inactivating mutations in the ARID1A tumor suppressor gene. These mutations are known genetic drivers...

Glucose under female hormones: diabetes incidence or gender coincidence?

Beside the current pandemic, there are non infectious pandemics that started much earlier. Diabetes is declared by WHO as a pandemic of alarming proportions...

Colon cancer: why does it drops with age, while stems up with youth?

As cancer death rates drop overall, doctors have noted a frightening anomaly: deaths from colorectal cancer in people under 55 appear to be creeping...

Prostate cancer: when a single aminoacid makes the difference between “stasis” and metastasis

An increased awareness on a molecular level of what mechanisms prostate cancer cells use to become mobile and start spreading may in the long...

Brain stroke by vessel damage: trip to the cellular core to bring knowledge to the surface

The brain is our most energy-hungry and metabolically active organ. It is responsible for our thoughts, ideas, movement and learning skills. Our brain is...

Inflammation, immunity, diet and sleep: who regulates who?

Inflammation, which is the root cause of autoimmune disorders including arthritis, type 1 diabetes, irritable bowel syndrome and Crohn's disease, has unexpected effects on...

Happy signal on Hippo pathway: cancer growth likes it contactless for spreading

Like subway commuters on a crowded train, cells generally prefer not to be packed in too tightly. In fact, they have set up mechanisms...

How many gene SNPs are still involved in Crohn’s? Let’s get JAK 2 the future

Researchers at Children's Hospital of Philadelphia (CHOP) have pinpointed a genetic variation responsible for driving the development of inflammatory bowel disease (IBD). The genetic...

Linking breast cancer to a genetic syndrome: common proteins, easier way to treat?

An international team of researchers led by scientists at Baylor College of Medicine has new insights into the function of neurofibromin, a tumor suppressor...

Liver cirrhosis and diabetes: they might share more “early” mechanisms than expected

Around 28 million people in the U.S. have type-2 diabetes, characterized by high blood sugar levels, a condition that can lead to many other...

Innate immunity connected to gut microbiota: the guests teach the host how to behave

Newborns face unique immunological challenges immediately after birth. As they depart a relatively sterile fetal environment, they are abruptly exposed to a multitude of...

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