Tag:

histone deacetylase

Expanding the roots or letting them committ: either way metabolism rules tissue “stamina” in good and bad fates

Stem cell proliferation and differentiation Stem cells have garnered significant attention in biomedical research due to their unique capacity for self-renewal and differentiation into various...

Human brain lift the HAT to greet life and aging: and modulate “his-tone” acetylation to develop and TIP its memories

The importance of gene transcription for normality To transcribe the information contained in our genes or to repair the dozens of breaks that occur daily...

DNA is where pluripotency STEMS: but mitochondria “renew it all” with their protein networks “edging” to death

Mitophagy is a selective form of macro-autophagy in which unwanted or damaged mitochondria are preferentially targeted for degradation at the auto-phago-lysosome, as an adaptative...

Lactate: that useless disposable junk, working as a genetic regulator in cancer cells

Described by Otto Warburg a century ago, accelerated glucose consumption and lactate production under fully aerobic conditions is ubiquitous in solid cancers. Observations of...

Osteoporosis surfs epigenetics: is histone methylation relying on gender to take its effects?

Nearly 19% of american women aged 50 and older have osteoporosis in their hips and lower spines. Osteoporosis-associated weakening of the bones increases the...