Tag:

mitochondria

Aminoacids and fats meet for “malignant” purposes: reexploring antipsychotic drugs paving the way for metabolic wreck

Glioblastoma (GBM) is the most lethal brain tumor, with a median survival rate of merely 12-16 months after diagnosis. Despite surgical, radiation and chemotherapy...

DNA is where pluripotency STEMS: but mitochondria “renew it all” with their protein networks “edging” to death

Mitophagy is a selective form of macro-autophagy in which unwanted or damaged mitochondria are preferentially targeted for degradation at the auto-phago-lysosome, as an adaptative...

Cancer kills by lactate: how cellular junk becomes a signal to acquire more fuel and waste the body to death

Cachexia is a complex metabolic syndrome associated with rapid loss of body weight, mainly loss of fat and lean muscle. Patients with cancer cachexia...

Antioxidants: not all of them match for mitochondrial needs

Mitochondria are tiny structures in human and animal cells that produce energy through an integrated series of chemical reactions known as the respiratory chain...

NAD+: does the hidden metabolism mirrors to tissue health?

Nicotinamide adenine dinucleotide (NAD+) is called the "anti-aging molecule" because research has shown that its levels fall with age and that restoring them can...

Cancer stem cells: an “old glory” works unexpectedly great against

Cancer stem cells (CSCs), also known as cancer-causing cells, are a hot topic among researchers. These cells are resistant to current treatments and play...

Silver bullets for cancers: now it’s time to believe it “on the word”

Apart from the fiction related to werewolves, there has always been talk of finding a "silver bullet" to kill tumors, as declared by the...