Tag:

transcription factor

RanBP2 in cancers: a SUMO fighter on the “surface” to be defeated in the “core”

The nuclear pore complex protein RANBP2 has emerged as a critical factor in the development and progression of various solid malignancies. As a SUMO...

FOXes R 2 clever to go undetected: but when it comes to children, “targeted” shots are needed

Pediatric tumors are a field of oncology that has always had special attention that needs no explanation. Tumors such as neuroblastoma and medulloblastoma are...

Il fattore LXR-beta: un recettore nucleare che dal metabolismo passa al controllo di ansia e depressione

Cos'è LXRβ? LXRβ, che appartiene alla famiglia dei recettori nucleari dei fattori di trascrizione attivati ​​da ligando, controlla il metabolismo del colesterolo e l'infiammazione. Diversi...

AP-1: a keymaster FOStering the JUNction among several tissues by wERKing on the cellular MAPk

AP-1: ID and biological functions AP-1 (Activator Protein-1) is a transcription factor that plays a key role in regulating gene expression involved in a wide...

Aminoacids and fats meet for “malignant” purposes: reexploring antipsychotic drugs paving the way for metabolic wreck

Glioblastoma (GBM) is the most lethal brain tumor, with a median survival rate of merely 12-16 months after diagnosis. Despite surgical, radiation and chemotherapy...

BLIMP-1, FOXP3, IRF4 e la chinasi SGK1: i componenti che innescano la comparsa di sclerosi multipla da troppo sale

Più di due decenni fa, un team di ricerca nel laboratorio di David Hafler scoprì un tipo di cellula T negli esseri umani che...

A DHD does not open the “gate”: rather the correct nutrient sequence opens the gut wormhole toward brain’s universe

Introduction ADHD is a childhood neurodevelopmental disease marked by difficulty paying attention, impulsive behavior, and hyperactivity. The disease is associated with various mental problems, addictions,...

Pitavastatin: the future official drug to prevent pancreatic cancer?

Chronic inflammation is a leading cause of cancer worldwide. A new study by researchers at the Mass General Cancer Center, a founding member of...