Tags Cancer cells

Tag: cancer cells

MCL-1 to the rescue: BH domains set 3 breast cancer from death

A protein frequently found in high levels in breast cancer cells helps tumors to survive and grow, and could be targeted with a new...

Estrogen receptors, signaling and targeting: in the midst of molecules to beat breast cancer

Estrogen receptors: how do they work? The estrogen receptor exists in two forms, ERα and ERβ, that are transcribed from unique genes and have different...

Marrow Stem Akt: researchers MAPKing signaling tRAFfic to find answers AT RApid pace

All-trans retinoic acid (ATRA), an active metabolite of vitamin A, regulates gene expression in a number of physiological processes, including embryogenesis, vision, growth, skin...

Every creature is fine but cancer: the redox strategy to beat the monster

The major cellular antioxidant is glutathione (GSH) which has the ability to be produced and regenerated after oxidation. The enzyme responsible for the process...

Against aggressive cancers: a game of thrones where the humble glutamine becomes the queen

Up to 60% of ovarian clear cell carcinomas (OCCC) have inactivating mutations in the ARID1A tumor suppressor gene. These mutations are known genetic drivers...

Fighting cancer, aging and neurotroubles: a tale of aminoacids, enzymes and inhibitors

Investigating an enzyme that stops cells from dividing could be a fruitful avenue for research into how to slow aging and treat aging-related diseases....

Metabokilling resistant leukemia: the old avenue with its alleys has not be forgotten after all

Leukemia is a group of blood cancers that results in excess amounts of white blood cells. There are both chronic forms of leukemia that...

Aspirin’ beating cancer, stat: prevention has now three agents met-for-mean

Lung cancer is a top death cause worldwide and active prevention by drugs is not perfprmed. Combined use of aspirin, statins, and metformin is...

Prostate cancer: when a single aminoacid makes the difference between “stasis” and metastasis

An increased awareness on a molecular level of what mechanisms prostate cancer cells use to become mobile and start spreading may in the long...

Dealing with the “hammer to fall”: a precise target to be struck for an optimal cell killing

Lung cancer accounts for a quarter of all cancer deaths, and non-small cell lung cancer makes up 84% of all lung cancer cases. Targeted...

Death comes with a Sting: but venom must be enhanced out of it

Scientists at Scripps Research have discovered a molecule that can activate a natural immune-boosting protein called STING (short for STimulator of INterferon Genes). The...

Growth factor-like effects: how blood pressure drugs take away the “hype” from cancer risk

Angiotensin-converting enzyme inhibitor (ACE-i) or angiotensin II receptor blocker (ARB) medications are prescribed for conditions such as heart failure, high blood pressure or heart...

Bitter expectances from sweet “oses”: how to take advantage over a cancer mutation

Like any cells in the body, cancer cells need sugar ­– namely glucose – to fuel cell proliferation and growth. Cancer cells in particular...

Happy signal on Hippo pathway: cancer growth likes it contactless for spreading

Like subway commuters on a crowded train, cells generally prefer not to be packed in too tightly. In fact, they have set up mechanisms...

Phosphatase 2 A control: the undruggable suppressor takes the challenge out of his pocket

A team of scientists led by the University of Michigan Rogel Cancer Center and Case Comprehensive Cancer Center has identified the binding site where...

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