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transcription factors

The host and the guest challenge each other: chemistry games help the one doing the job of the other

Reactive oxidant species (ROS) accumulation is key to osteoclast differentiation, a phenomenon related to bone reabsorption and the onset of osteoporosis. Plant-derived polyphenols that...

Bach 2 the skintrack: a-topic to explore to treat dermatitis making easier MAREs to trot

Atopic dermatitis is an allergy that affects an average of about 5% of the general population, with symptoms closely related to social stress. In...

Opioid and endocannobinoid signaling: surface reach “the core” to regulate our mood

Opioid and endocannabinoid transmission is not just an “acute” signaling system related to pleasure, analgesia, or emotional regulation; it is, in fact, a modulatory...

“Lend me your proteins to keep the balance”: here’s the shadowy, helpful role of platelets in immunity

Monocytes, a special type of white blood cell, secrete cytokines as inflammatory messengers that are crucial for an adequate immune response. Monocytes are white...

Tetracyclins: old antibiotics committable for human diseases?

Background Tetracyclines are an old class of antibiotics that have been used for specific infections such as brucellosis, Lyme disease, rickettsiosis (e.g. Rocky Mountain spotted...

Expanding the roots or letting them committ: either way metabolism rules tissue “stamina” in good and bad fates

Stem cell proliferation and differentiation Stem cells have garnered significant attention in biomedical research due to their unique capacity for self-renewal and differentiation into various...

Genes in a bottle: grammar, codes, writing and spelling inside that little sphere called nucleus

Over an organism's lifetime, its genome changes very little. What does change, constantly, are which proteins the cell produces in response to damage, changes...

DNA repair going APE and strand breaks fixing with ATM: please no cash, just redox and contact bases

New research from a team of genome scientists and DNA damage response (DDR) experts breaks new ground in understanding the function of a protein...