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Tag: bone marrow

Together is better than alone: did you put a Notch in your belt to remember it?

Australian scientists have found a new and effective way to treat a particularly aggressive blood cancer in children. Acute lymphoblastic leukemia (ALL) is the...

Sick to the bone: how a growth factor leads the marrow to drying up its normal stems

Bone marrow failure due to acute myeloid leukemia (AML) is a significant factor behind the disease's high rate of morbidity and mortality. Previous studies...

SickLE news: will the new drug open a new bloody hope?

Sickle cell disease is a group of inherited disorders that affect red blood cells. Healthy red blood cells are flexible discs. In people with...

Physical and calorie control against leukemia’s marrow residual: the IDEAL trial summary

Overweight children and adolescents receiving chemotherapy for treatment of leukemia are less successful battling the disease compared to their lean peers. Now, research conducted...

Marrow Stem Akt: researchers MAPKing signaling tRAFfic to find answers AT RApid pace

All-trans retinoic acid (ATRA), an active metabolite of vitamin A, regulates gene expression in a number of physiological processes, including embryogenesis, vision, growth, skin...

Anti-itches to the rescue: unconventional and repurposing fraternizing against leukemia

Acute myeloid leukaemia (AML) is a clinically and biologically heterogeneous disease characterized by the accumulation of immature transformed myeloid progenitors in bone marrow. Although...

EneMY Coin: one side enhances energy while the other escapes immunity

Protein c-Myc is a major oncogene that is estimated to drive the development of almost 500.000 new cancer cases in the US every year....

Metabokilling resistant leukemia: the old avenue with its alleys has not be forgotten after all

Leukemia is a group of blood cancers that results in excess amounts of white blood cells. There are both chronic forms of leukemia that...

Exploiting leukemia stem cells’ hunger for aminoacids: old notions get new dresses

Most of animal cells rip apart sugar to release energy. Sometimes they rip apart fats, and in special circumstances, cells can even metabolize proteins....

Does bone stem its shape from the marrow? So it would seem, but it’s a “fatty” matter

Healthy bone maintenance is a balance between osteoblasts, which secrete the materials necessary to form new bone, and osteoclasts, which absorb old bone material...

Osteotroubles shift: porosis focuses on chemokines, arthrosis gets old porosis’ biphosphonates

Osteoporosis is the most common age-related bone disease which affects hundreds of millions of individuals worldwide. It is estimated that one in three women...

How many gene SNPs are still involved in Crohn’s? Let’s get JAK 2 the future

Researchers at Children's Hospital of Philadelphia (CHOP) have pinpointed a genetic variation responsible for driving the development of inflammatory bowel disease (IBD). The genetic...

Innate immunity connected to gut microbiota: the guests teach the host how to behave

Newborns face unique immunological challenges immediately after birth. As they depart a relatively sterile fetal environment, they are abruptly exposed to a multitude of...

Leukemia field: rearranging and targeting are in both sides of the coin

Results from a study conducted by St. Jude Children's Research Hospital and the Munich Leukemia Laboratory were presented today as a late-breaking abstract at...

Cancers and aminoacids: (mi)splicing the building blocks at the inteRNAl level through diet?

A research team from the Johns Hopkins Kimmel Cancer Center reports it has discovered a metabolic vulnerability in multiple types of cancer cells that...

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