Tag:

protein kinase

Age is no guarantee of efficiency, and youth is no guarantee of innovation: forskolin vs. brain cancer

Glioblastoma, the most malignant form of brain cancer, is notoriously difficult to treat, largely due to the cancer cell's ability to divide uncontrollably and...

AML fighting is not MENINgless: SRChing Akt-ting kinases and a nuclear-mine to kill the stem

Acute myeloid leukemia (AML) is the deadliest form of leukemia, with a median survival of less than nine months and a 5-year survival rate...

Complement-aRy roles for immune proteins in skin cancer: C5 triggers metastasis with α “q” of signals

Cutaneous squamous cell carcinoma (cSCC), a type of skin cancer, it's the second most common type of skin cancer, after basal cell carcinoma and...

The host and the guest challenge each other: chemistry games help the one doing the job of the other

Reactive oxidant species (ROS) accumulation is key to osteoclast differentiation, a phenomenon related to bone reabsorption and the onset of osteoporosis. Plant-derived polyphenols that...

An IGFBP receptor sows death form above: meet TMEM219, a face-off(ender) of gut staminality

An international study led by Dr. Paolo Fiorina from Boston Children's Hospital and in collaboration with researchers from University of Milan highlights the beneficial...

Personalized medicine in type 2 diabetes: the influence of phospho-proteome and gender

Type 2 diabetes (T2D) is a rapidly growing metabolic condition worldwide characterized by increased blood glucose levels during fasting or after food consumption. T2D...

Bone strenghts funNELL 2 genetic: kinases may be no the only FAKtotum in cellular AKTs

Osteoporosis, a widespread bone disease affecting millions globally, is caused by an imbalance between bone resorption and formation. Current treatments primarily inhibit bone resorption,...

Melanoma drug resistance get overcome: without GSK3 cells are B-Raft of advantage

Melanoma is a type of skin cancer in which nearly half of patients have mutations in the BRAF gene that accelerate tumor growth. Although...